mosig uni jena
(2) ... 07747 Jena, Germany. With UC2 (You-See-Too) we present an inexpensive 3D-printed microscopy toolbox. Research Award of the Federal Ministry of Food and Agriculture for the development of organ-on-chip models as replacement method for animal experimentation, Innovation Award of the BioRegions Germany 2016, Animal Welfare Award of the Federal State of Thuringia 2014. Author information: (1)Center for Sepsis Control and Care, Jena University Hospital, 07747, Jena, Germany. establishment and characterization of a microfluidically supported in vitro organoid model of the Gerhard G. Paulus. Weitere Pflichtangaben finden Sie in unserer Datenschutzerklärung. For postdocs and staff, there … Electronic address: Alexander.MOSIG@med.uni-jena.de. Only verified researchers can join ResearchGate and send messages to other members. Alexander S. Mosig. Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany. In this reservoir, the fungus exists as a harmless commensal. The purpose of the present study was to investigate the effects of acute exercise on gene expression profiles (GEPs) of WBCs and to identify suitable genes that may serve as surrogate markers for monitoring exercise and... Ziel dieser Arbeit war es, anhand der Untersuchung von Genexpressionsprofilen (GEP) von Monozyten und T-Zellen weitergehende Erkenntnisse über die molekularen und zellulären Vorgänge in diesen Zellen bei der Entwicklung der Atherosklerose von Patienten mit Familiärer Hypercholesterinämie zu erhalten. Central institutions and faculties of Jena University. T lymphocytes get in contact with affected organs (e.g., lung) or cells (e.g., erythrocytes), as well as with smoke components and bioactive molecules, whose production is triggered by tobacco smoke. Office: Carl-Zeiss-Str. Electronic address: alexander.mosig@med.uni-jena.de. Societies Learn more. Evaluation of epigenetic mechanisms in a septic liver model. ABCA1 expression is further decreased during monocyte to macrophage differentiation of FH monocytes compared to monocytes of healthy individuals. PD Dr. Alexander Mosig Institute for Biochemistry II und Center for Sepsis Control and Care, Universitätsklinikum Jena „Human microphysiological systems as in vitro platform for emulation of gut, liver, and lung in disease modelling and infection research “ Wednesday Feb 20th, 11:15 BFS, Seminar Room 17.1/2 Schubertstr. Mit dem Benutzen der Webseite erklären Sie sich der Nutzung von Cookies einverstanden. Center for Sepsis Control and Care (CSCC), French Institute of Health and Medical Research, Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD), Center for Infectious Disease and Infection Control & Deparment of Anesthesiology and Intensive Care Medicine, Anesthesiology and Intensive Care Medicine, Rapid Target Binding and Cargo Release of Activatable Liposomes Bearing HER2 and FAP Single-Chain Antibody Fragments Reveal Potentials for Image-Guided Delivery to Tumors, SARS-CoV-2 causes severe alveolar inflammation and barrier dysfunction, Staphylococcus aureus Lung Infection Results in Down-Regulation of Surfactant Protein-A Mainly Caused by Pro-Inflammatory Macrophages, VEGF Triggers Transient Induction of Autophagy in Endothelial Cells via AMPKα1, UC2 - A Versatile and Customizable low-cost 3D-printed Optical Open-Standard for microscopic imaging, Co-infection with Staphylococcus aureus after primary influenza virus infection leads to damage of the endothelium in a human alveolus-on-a-chip model, The PPARγ antagonist 2-chloro-5-nitro-N-phenylbenzamide (GW9662) triggers PLIN2 expression via PPARδ and induces lipogenesis and triglyceride accumulation in human THP-1 macrophages, The vitamin E derivative α-amplexichromanol as anti-inflammatory lead inspired from traditional African medicine, Keeping Candida commensal – How lactobacilli antagonize pathogenicity of Candida albicans in an in vitro gut model, A three-dimensional immunocompetent intestine-on-chip model as in vitro platform for functional and microbial interaction studies, CAAP48, a New Sepsis Biomarker, Induces Hepatic Dysfunction in an in vitro Liver-on-Chip Model, UC2 – A 3D-printed General-Purpose Optical Toolbox for Microscopic Imaging, Candida albicans β-Glucan Differentiates Human Monocytes Into a Specific Subset of Macrophages, Endogenous metabolites of vitamin E limit inflammation by targeting 5-lipoxygenase, Raman spectroscopic investigation of the human liver stem cell line HepaRG, Microphysiological systems meet hiPSC technology – New tools for disease modeling of liver infections in basic research and drug development, Corrigendum: Monocyte-induced recovery of inflammation-associated hepatocellular dysfunction in a biochip-based human liver model, Functional analyses of RUNX3 and CaMKIINα in ovarian cancer cell lines reveal tumor-suppressive functions for CaMKIINα and dichotomous roles for RUNX3 transcript variants, Short-term treatment with taurolidine is associated with liver injury, Preservation of Cell Structure, Metabolism, and Biotransformation Activity of Liver-On-Chip Organ Models by Hypothermic Storage, Thermo-responsive cell culture carrier: Effects on macrophage functionality and detachment efficiency, Tribbles 2 mediates cisplatin sensitivity and DNA damage response in epithelial ovarian cancer, Evaluation of HepaRG cells for the assessment of indirect drug-induced hepatotoxicity using INH as a model substance, Organs-on-a-Chip: Neue Perspektiven in der Medikamentenentwicklung und Personalisierten Medizin, Selective upregulation of TNFα expression in classically-activated human monocyte-derived macrophages (M1) through pharmacological interference with VATPase, Modulation of actin dynamics as potential macrophage subtype-targeting anti-tumour strategy, High‐Saturated‐Fat Diet Increases Circulating Angiotensin‐Converting Enzyme, Which Is Enhanced by the rs4343 Polymorphism Defining Persons at Risk of Nutrient‐Dependent Increases of Blood Pressure, Novel approach for the prediction of cell densities and viability in standardized translucent cell culture biochips with near infrared spectroscopy, Crossing the blood-brain barrier: Glutathione-conjugated poly(ethylene imine) for gene delivery, Organ-on-chip models: new opportunities for biomedical research, An integrative microfluidically supported in vitro model of an endothelial barrier combined with cortical spheroids simulates effects of neuroinflammation in neocortex development, Recruitment of CD16+ monocytes to endothelial cells in response to LPS treatment and concomitant TNF release is regulated by CX3CR1 and interfered by soluble fractalkine, Monocyte-induced recovery of inflammation-associated hepatocellular dysfunction in a biochip-based human liver model, A human macrophage – hepatocyte co-culture model for comparative studies of infection and replication of Francisella tularensis LVS strain and subspecies holarctica and mediasiatica, A new fluorescent dye for cell tracing and mitochondrial imaging in vitro and in vivo, High fat diet induced association of anti-inflammatory phospholipid and CRP levels in human adipose tissue in the NUGAT study, A Microfluidically Perfused Three Dimensional Human Liver Model, Comparison of the uptake of methacrylate-based nanoparticles in static and dynamic in vitro systems as well as in vivo, A biochip-based liver organoid model of human sepsis. Institut für Biochemie II Universitätsklinikum Jena Nonnenplan 2-4 07743 Jena Telefon: +49 3641 9 390 910 Telefax: +49 3641 9 396 402 alexander.mosig@med.uni-jena.de In an earlier study, we identified multiple genes as hypermethylated in tumors of patients with poor prognosis. (2015). The Friedrich Schiller University on social media: Research Group Leader Biochip-based organ models. Correspondence: Dr. Alexander S. Mosig (alexander.mosig@med.uni-jena.de), Institute of Biochemistry II, Jena University Hospital, Am Nonnenplan 2–4, 07743 Jena, Germany.Search for more papers by this author. Mosig, S., et al. Friedrich Schiller University, Institute of Microbiology. alexander.mosig@med.uni-jena.de. Lehrstuhl für Digitale Bildverarbeitung Raum 1220 Ernst-Abbe-Platz 2 News. Hepatic α-TOH catabolism results in intermediate formation of long-chain metabolites (α-LCMs(5)) α-13'-hydroxy- and α-13'-carboxychromanol (α-13'-OH(6) and α-13'-COOH(7)). Taurolidine has been used for peritonitis, oncological and catheter-lock treatment because of its anti-inflammatory properties. Histogram bars indicate the mean ± SD (* p < 0.05, ** p < 0.01). The targeted drug delivery to the central nervous system represents one of the major challenges in pharmaceutical formulations since it is strictly limited through the highly selective blood-brain barrier (BBB). Analysis of gene expression by qRT-PCR for CD36 and LRP1. Since obesity is triggered by energy dense diets, we hypothesized that nutrient induced intestinal hormones such as glucose-dependent insulinotropic peptide (GIP) may directly st... Hemodynamic forces generated by the blood floware of central importance for the function of endothelial cells (ECs),which form a biologically active cellular monolayer in blood vessels and serve as a selective barrier for molecular permeability. CD91/Lrp1 is not involved in nLDL uptake. Liposomes represent suitable tools for the diagnosis and treatment of a variety of diseases, including cancers. We are a changing group of students of the Friedrich-Schiller-University Jena which is traveling all over the world to learn first hand about diplomacy in MUNs or "Model United Nations". Raman spectroscopic imaging was used to visualize the cell nuclei by means of false color imaging using a marker band, and a cell segmentation w... Complex cell culture models such as microphysiological models (MPS) mimicking human liver functionality in vitro are in the spotlight as alternative to conventional cell culture and animal models. sandy.mosig@mti.uni‐jena.de; Molecular Hemostaseology, Friedrich‐Schiller‐University of Jena, Jena, Germany. The Functional Photonic Nanostructures junior research group at the Institute of Applied Physics is dedicated to the study of the fundamental optical properties and potential applications of subwavelength … Systemic vitamin E metabolites have been proposed as signaling molecules, but their physiological role is unknown. In the presence of ECs a lipopolysaccharide (LPS)-stimulus led to a significant increase... Liver dysfunction is an early event in sepsis-related multi-organ failure. Jena University Hospital Center for Sepsis Control and Care Dr. Alexander Mosig, Email: alexander.mosig[at]med.uni-jena.de, Phone +49 03641-9346418 References 1. Author information: (1)Department of Gynecology, Jena University Hospital-Friedrich Schiller University Jena, 07747 Jena, Germany. We t... White blood cells (WBCs) express tens of thousands of genes, whose expression levels are modified by genetic and external factors. The development of therapeutic substances to treat diseases of the central nervous system is hampered by the tightness and selectivity of the blood-brain barrier. & Care, Jena University Hospital, Jena, Germany and InstituteofBiochemistryII, Jena University Hospital, Jena, Germany Alexander.MOSIG@med. Institute of Biochemistry II University Hospital Jena Nonnenplan 2-4 07743 Jena Phone: +49 3641 9 390 910 Fax: +49 3641 9 396 402 alexander.mosig@med.uni-jena.de Quality control of microarry raw data. Lehrstuhl für Digitale Bildverarbeitung Friedrich-Schiller-Universität Jena 07737 Jena, Germany . qRT-PCR analysis of SREBP gene expression of FH patients receiving statin medication and FH patients without statin therapy. Studies on Franci... Mitochondria contribute to redox and calcium balance, and apoptosis thus regulating cellular fate. Delivery&Parcel Address. Since 2018 Co-Founder Dynamic42 GmbH (Spin off from Jena University Hospital) Since 2017 Divisional Head Animal Labs and Replacement Methods. The system is based on concepts of modular development, rapid-prototyping and all-time accessibility using widely available off-the-shelf optic and electronic components. Image: Jan-Peter Kasper (University of Jena) Service. Service we provide. (1) Background: Epithelial ovarian cancer (EOC) is the most lethal cancer of the female reproductive system. This also applies to the exams. We here report the establishment of a liver organoid that integrates NPCs in a vascular layer composed of endothelial cells and tissue macrophages and a hepatic layer comprising stellate cells co... We have established an electroporation protocol for transfection of premature adherent human THP-1 macrophages using Lonza Nucleofector technology. Although the viral infection originates in the respiratory system, it is unclear how the virus can overcome the alveolar barrier, which is observed in severe COVID-19 disease courses. Molecular Hemostaseology, Friedrich‐Schiller‐University of Jena, Jena, Germany. It is able to infect and replicate within Kupffer cells, specialized tissue macrophages of the liver, and to modulate the immune response upon infection to its own advantage. Microfluidically supported biochip design for culture of endothelial cell layers With improved perfusion conditions. Statin therapy has no effect of SREBP gene expression in monocytes. 12 Institute of Biochemistry II, Jena University Hospital, 07743 Jena, Germany; Center for Sepsis Control and Care, Jena University Hospital, 07747 Jena, Germany. A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Institute of Biochemistry IIUniversity Hospital JenaNonnenplan 2-407743 JenaPhone: +49 3641 9 390 910Fax: +49 3641 9 396 402alexander.mosig@med.uni-jena.deHomepage. (11)Institute of Pharmacy, Friedrich Schiller University Jena, Philosophenweg 14, D-7743 Jena, Germany. Increased CD36 and CD91/Lrp1 levels on the surface of monocytes from FH patients and their role in LDL uptake. Long-chain metabolites of vitamin E: A new class of regulatory metabolites modulating atherogenic processes? We will see you in Jena in the winter semester 2020/21—partly on site, partly online 10 July 2010 10 July 2010 Educational operations of the winter semester 2020/21 at the Friedrich Schiller University will start on 2 November 2020 and will be conducted—at least partially—on site. Pneumonia is one of the most common infectious diseases worldwide. Was aber sind Organ-on-a-Chip-Systeme und wo liegt ihre Anwendung? In this context, Staphylococcus... Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor family playing pivotal roles in regulating glucose and lipid metabolism as well as inflammation. Cell type-specific delivery of short interfering RNAs by dye-functionalised theranostic nanoparticles. 3 Center for Electron Microscopy, Jena University Hospital, Friedrich Schiller University Jena, Ziegelmuehlenweg 1, 07743 Jena, Germany; frank.steiniger@med.uni-jena.de 4 Center for Sepsis Control and Care, Institute of Biochemistry II, Jena University Hospital, human liver sinusoid. There are no tuition fees at the Friedrich Schiller University Jena. Image: Jan-Peter Kasper (University of Jena) The Abbe Center of Photonics (ACP) hosts fundamental and applied research in optics and photonics. Raasch M, Rennert K, Jahn T, Peters S, Henkel T, Huber O, Schulz I, et al. This study investigates whether the VEGF/AMPK pathway regulates autophagy in endothelial cells and whether this is linked to its pro-angiogenic role. Contrary to the assumption that ACE levels are stable, circulating ACE has been shown to be altered in obesity and weight loss. jena.de/Karriere or write an Email to alexander.mosig@med.uni-jena.de Reference number: DM23/2020 (internal and external) Application deadline: 30. joachim [dot] denzler [at] uni-jena [dot] de: Phone: +49 3641 946420: Consultation hour: Monday, 2-3 pm (during the lecture periods) Postal Address. The centers of the boxes represent the median of the genes, upper and lower ends of the boxes represent the 75th and 25th quartiles, respectively. Glucan derived from cell walls of Candida albicans is a potent immune modulator. The system is based on concepts of modular development, rapid-prototyping and all-time accessibility using widely available off-the-shelf optic and electronic components. For efficient electroporation detachment of adherent cells is necessary. Aim was to identify methylated genes with functional involvement in cisplatin-resistance development of epithelial ovarian cancer (EOC). Image: Jan-Peter Kasper (University of Jena) Friends and Patrons. 2008 - 2012 University Professor (W2) for Nutritional Biochemistry, Institute of Nutrition, FSU Jena 2006 Habilitation and venia legendi in biochemistry and cell biology, University of Münster 2003 - 2008 Head of Research Group, Leibniz Institute of Arteriosclerosis Research Münster International Organizations and Crisis Management - IOCM in short - is the masters degree in political science of the Chair for International Relations at the Friedrich-Schiller-University Jena. ); nderim_kryeziu@hotmail.com (N.K. To create a platform for the investigation of the underlying mechanisms, we established a three-dimensional micro... Sepsis is a leading cause of mortality in the critically ill, characterized by life-threatening organ dysfunctions due to dysregulation of the host response to infection. Marko Gröger. Room: 08N05 Phone: +49-3641-9-46480 This corrects the article DOI: 10.1038/srep21868. Search for more papers by this author. Glucose-dependent insulinotropic peptide (GIP) increases adipose tissue expression and blood levels of MCP-1 in humans and links high energy diets to inflammation: A randomized trial. The data provided show that NPC1 as well as ABCA1 expression is deceased in FH monocytes. in drug development and in... Aims/hypothesis Obesity is associated with elevated monocyte chemoattractant protein-1 (MCP-1), a proinflammatory chemokine related to diabetes and cardiovascular disease. These authors contributed equally to this work.Correspondence: Bachstrasse 18, 07743 Jena, Germany. Infections with SARS-CoV-2 lead to mild to severe coronavirus disease-19 (COVID-19) with systemic symptoms. B: Whisker box plots of log2 transformed microarray raw data. mRNA expression of A: CD36 and B: LRP1 is elevated in monocytes of patients with homozygous or heterozygous FH compared to controls. non-parenchymal cells closely reflecting tissue archit... Background (4)Institute of Biochemistry II, Jena University Hospital, Germany; Center for Sepsis Control and Care, Jena University Hospital, Germany.
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